Pharmacological category:
Anabolic-androgenic steroid
Mechanism of medicine action:
Methandienone functions by binding and activating the androgen receptor (AR), resulting in significant increases in protein synthesis, glycogenolysis, and muscle strength within a short timeframe. While it can be converted into a more potent Androgenic-anabolic steroid (AAS), methyl-1-testosterone (17α-methyl-δ1-DHT), by the enzyme 5α-reductase, the drug has a minimal affinity for this enzyme and thus produces only negligible amounts of methyl-1-testosterone. Consequently, drugs like finasteride and dutasteride, which are 5α-reductase inhibitors, are ineffective in reducing the androgenic effects of methandienone.
Side effects:
Oily skin, acne, seborrhea, increased facial/body hair growth, scalp hair loss, and virilization are all possible androgenic adverse effects. Gynecomastia and fluid retention are two estrogen-related adverse effects that might develop. There are case reports of gynecomastia. Metandienone, like other 17-alkylated steroids, has a risk of hepatotoxicity, and if used for an extended period of time without proper safeguards, it can cause liver damage.
Dosage:
The lowest dose of Methandienone you’ll find is 15 mg on average. People who have previously used Methandienone tend to raise the dosage by 5 to 10 mg every cycle. Even for the most experienced users, exceeding Methandienone 50 mg is not recommended due to the fast increase in the severity of the negative effects.
